Includes sites related to processes of the Central Dogma of Genetics: transcriotion to mRNA, mRNA splicing, translation to polypeptides, modification of the resulting polypeptides by specific proteolysis and conjugation to carbohydrates, lipids and prosthetic groups. Also includes control of the processes: pre-transcriptional by factors controlling transcription to mRNA and post-transcriptional control by RNA interference (iRNA). A separate sub-category includes sites related to viral reverse transcription.
Overview of different aspects of gene expression, including transcription, chromatin modification, and analysis of whole genomes, from Massachusetts Institute of Technology, Cambridge, Mass, USA. web.wi.mit.edu/young/pub/regulation.html
Explanation of how the information encoded in mRNA is translated into a polypeptide. Includes differences between prokaryotes and eukaryotes by John W. Kimball, now retired from Harvard College. users.rcn.com/../BiologyPages/R/Ribosomes.html
Illustrated explanation of the ribosomal protein synthesis by Gwen V. Childs, University of Texas, Galveston, TX. cellbio.utmb.edu/cellbio/ribosome.htm
An online textbook on chromosomes, principles of genetic engineering, basic molecular genetics and experimental methods. opbs.okstate.edu/~melcher/MG/FMG01.html
Mercier G., Denis Y., Marc P., Picard L. and Dutreix M.: Transcriptional induction of repair genes during slowing of replication in irradiated Saccharomyces cerevisiae. Mutation Research 487 (dec 2001)157-172: article and supporting background data. www.curie.u-psud.fr/Equipe_Dutreix/web/article1/tab-art1.html
Forum to integrate various aspects of mammary gland biology, including cellular and developmental aspects, and to promote collaborations and the exchange of ideas, knowledge and resources at NIH, Maryland. mammary.nih.gov
Resource for intervention in the key steps in post-translocation regulatory process, with analysis tools and implications in pathologies. Maintained by Exonhit Therapeutics SA, Paris, France. www.exonhit.com/alternativesplicing
Report on a project to analyze the transcriptional regulatory circuitry of the yeast cell. From the Young Lab at the Whitehead Institute for Biomedical Research. web.wi.mit.edu/young/expression/home.html
Clear explanation of the process of comparing the gene expression in two cell populations or tissue samples by fluorescent microarray technique. www.cs.wustl.edu/~jbuhler/research/array
Wikipedia article on the process in eukaryotes in which the splicing process of a pre-mRNA can lead to different ripe mRNA molecules and therefore to different proteins. en.wikipedia.org/wiki/Alternative_splicing
Wikipedia article on enhancers, short pieces of DNA which bind to trans-acting factors to enhance transcription levels of genes. en.wikipedia.org/wiki/Enhancer
Wikipedia article on sections of genes that are eliminated by splicing in the formation of mature mRNA and therefore not expressed as proteins. en.wikipedia.org/wiki/Intron
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